Vietnam War veteran John Rambo (Sylvester Stallone) suffers from post-traumatic stress disorder and lives on an inconspicuous ranch in Arizona, interrupted by small part-time work. One day, an old friend of the hero Maria tells Rambo that her granddaughter went missing after she went to a party in Mexico. John has no choice but to cross the Mexican-American border to find a girlfriend. Traveling to Mexico turns out for Rambo to be a real descent into hell, because there he discovers sex traffic organized by unscrupulous representatives of the drug syndicate. Enlisting the support of journalist Carmen Delgado (Dog Vega), whose stepsister was also abducted, Rambo must use all his skills to save the girls and deal with the cruel cartel leader once and for all.